Keeping your memory and thinking sharp, including APOE and the genes linked to Alzheimer's
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
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How it works
1Buy the report We email you a sign-in link.
2Attach your DNA file It's read on your computer.
3Read your report Your report is ready in a few minutes, as a PDF to keep.
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version.
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“I also got the one-on-one consultation with the genetic counselor and was thrilled with the experience. Very clear and efficient. Highly recommended!”
How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 38 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
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Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
Start here
One page tells you how to use the rest: skim the summary, pick one to three changes, look up the why only when you want it, and change one thing at a time.
How the report says to start
Called “START HERE: How To Use This Report” in the reportThe report's own four steps. From an example report made with a sample DNA file.
2
The science behind it, if you want it
The biology of amyloid and tau, rare inherited mutations versus common risk variants, APOE and fat transport, and the changeable risk factors behind dementia, for when you or your practitioner want to understand the mechanisms.
Chapters in this report
Precision Medicine For Alzheimer's Disease
As titled in the example report.
3
Your Recommendations Summary
A ranked, prioritized list of foods, nutrients, and lifestyle factors scored by the combined strength of your genetic signal. The practical starting point.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CSupplements name the exact form, here riboflavin 5'-phosphate for vitamin B2, because the form affects how well your body can use it.
DFood sits in the same list. Foods rich in sulfur rank alongside the supplements, so you can start with what you eat.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
4
Where your genes disagree
Where genes pull in different directions on the same intervention, both scores are shown instead of hiding the tension.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the reportItems that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
5
One page for each gene
Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
6
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for IL-6. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 38 genes across these areas.
Cholesterol, blood fats, and blood pressure
Amyloid, tau, and the brain's clean-up
Immune activity in the brain and body
Inflammation
Synapses and memory
Glutathione and antioxidant defense
Methylation, homocysteine, and B vitamins
Rare early-onset genes
See every area and gene
Cholesterol, blood fats, and blood pressure. How your body carries cholesterol and other fats, and how your blood vessels hold up (APOE, APOA2, ACE).
Amyloid, tau, and the brain's clean-up. How your cells sort and clear amyloid-beta, and how tau steadies the internal tracks neurons use to move material (SORL1, BIN1, PICALM, CLU, ABCA7, MAPT, FERMT2, CASS4, NME8).
Immune activity in the brain and body. How your immune system responds, including the brain's own immune cells, called microglia, and how briskly they clear debris (TREM2, CD33, MS4A, CR1, INPP5D, HLA-DRB1, CELF1, ZCWPW1).
Inflammation. How strongly you make the signals behind long-running, low-grade inflammation (IL-6, TNF-alpha, IL-1B).
Synapses and memory. How connections between neurons form, strengthen, and get pruned (MEF2C, PTK2B).
Glutathione and antioxidant defense. How much glutathione, the brain's main internal antioxidant, you can make and use (GCLC, GCLM, GSS, GSTP1).
Methylation, homocysteine, and B vitamins. How efficiently you clear homocysteine, and the forms of folate, B12, and choline the report suggests for your variants (DHFR, MTHFR, MTR, MTRR, MTHFD1, PEMT, COMT).
Rare early-onset genes. Rare changes in APP, PSEN1, and PSEN2 are linked to Alzheimer's disease that usually starts before age 65. A result here is a medical question rather than a nutrition one, to confirm with accredited clinical testing and a genetic counselor.
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is for anyone who wants a science-based plan for long-term memory and brain health, especially if Alzheimer's disease or dementia runs in your family, if you know or suspect you carry APOE e4, or if you are in midlife, when research suggests reducing risk counts most. If you are noticing changes in your memory now, see your doctor first.
If B vitamins and methylation are your main interest, the Methylation and Diet Report shares the methylation genes here and adds many more. The Healthy Aging Report also reads APOE, in a broader report on healthy aging. Choose this report if your focus is the brain.
The science, briefly
Why the same brain health advice matters more for some people
If Alzheimer's runs in your family, you have probably been told to eat well and stay active, and you may have wondered which parts of that advice matter most for you.
APOE and the fat on your plate
APOE carries fats through the blood and brain. People with the e4 form appear more sensitive to the type of fat they eat.
In your reportFor carriers, the report weighs Mediterranean-style eating and omega-3 fats more heavily, and flags saturated fat and added sugar.
Read the full explanation
APOE makes the protein that carries cholesterol and other fats through the blood and the brain. It comes in three common forms, e2, e3, and e4, and people who carry e4 appear more sensitive to the fat they eat. In a UK trial that recruited people by APOE type, those with one e4 copy saw a rise in C-reactive protein, a blood marker of inflammation, on high saturated fat diets, a rise not seen in people with two e3 copies. When DHA, an omega-3 fat from fish, was added to the same diet, their triglycerides, a type of blood fat, ended 30 percent lower than on the low-fat diet, against 17 percent in the e3 group. For carriers, the report points toward a Mediterranean diet, omega-3 fats, and walnuts, and away from saturated fat and added sugar.
ACE and blood pressure
ACE affects blood pressure and helps break down amyloid-beta. Blood pressure in midlife is a changeable risk factor for later cognitive decline.
In your reportThe report puts food and exercise supports for this pathway in context. Blood pressure is something you can measure directly.
Read the full explanation
ACE makes an enzyme that helps raise blood pressure, and it also breaks down amyloid-beta, the protein fragment that builds up in Alzheimer's disease. High blood pressure in midlife is among the better-established changeable risk factors for later cognitive decline, and it is a number you can check. The report points carriers toward omega-3 fats, garlic, nitrate-rich foods, and regular exercise, and away from a high-salt diet and sugar.
MTR, MTRR and the B12 you can use
MTR and MTRR recycle homocysteine using vitamin B12. Variants can affect this pathway even when folate intake is adequate.
In your reportThe report lists specific B vitamin forms. It also makes homocysteine a result to discuss with your doctor.
Read the full explanation
These two genes recycle homocysteine, an amino acid whose raised levels are associated with faster brain shrinkage and higher dementia risk, and the reaction depends on vitamin B12. Variants here can show up as a B12 problem even when folate intake is adequate, and a standard B12 blood test can look normal while the pathway underperforms. That makes a homocysteine test worth asking your doctor about. The report points carriers toward specific forms of vitamins B12, B2, and B6.
Those are three of the mechanisms. The report reads more than 160 markers across 38 genes, in eight areas.
Your APOE type, and why it depends on your DNA file
Your APOE type is set by two markers, rs429358 and rs7412. You carry two copies of the gene, so the result is a pair, such as e3/e4. When your file includes both, the report reads your type directly. Not every file does. DNA testing companies don't all read exactly the same markers, and the same company can change its list from one version of its test to the next, so some files carry only one of the two.
If your file has rs7412 but not rs429358, the report uses a neighboring marker, rs2075650, in the TOMM40 gene next to APOE. It often travels with e4, but the match is far from exact, so the result is an estimate of your APOE type rather than a confirmed one, and the report marks where confirmation is most worth considering. If your reading suggests you carry e4, and especially two copies, talk to your doctor about a clinical test that includes rs429358. If your file is missing rs7412, the report can't show your APOE type, and the rest of the report works as usual. You can see which of the two your file has by searching it for rs429358 and rs7412.
More on the science behind this report
Most advice about protecting your memory as you age is the same for everyone, usually a Mediterranean-style diet, regular exercise, good sleep, and an active mind. It is good advice, and it leaves out how differently people respond to it. Your genes influence how you handle cholesterol, how the brain's immune cells clear debris, how your blood vessels hold up, and how well you use B vitamins. Each of those responds to food and daily habits.
In 2024 the Lancet Commission on dementia estimated that about 45 percent of dementia cases could potentially be delayed or reduced by addressing 14 modifiable risk factors, among them high blood pressure, high LDL cholesterol, physical inactivity, and smoking. It is a population estimate rather than a personal forecast.
This report does not tell you whether you will develop Alzheimer's disease. It reads the genes studied in Alzheimer's research and turns them into a ranked, food-first plan for memory and brain health as you age.
Private by design
Your DNA file stays on your computer
Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
No. You pay once for this report, and there's nothing to renew or cancel.
Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
You need raw data from 23andMe, Ancestry, MyHeritage, or another DNA service. We do not sell kits, so order a test from one of them first, then download your raw data file from their site.
Can I do it on my phone?
For now, generating your report works best on a computer. Once it's ready, you can read the PDF on any device.
What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
Will this tell me whether I will get Alzheimer's disease?
No. It does not diagnose Alzheimer's disease or predict whether you will develop it. Most of the genes in this report shift the odds only slightly, and most people who carry higher-risk variants, including APOE e4, never develop the disease. What the report shows is which changes to food and daily habits have the most genetic support for you.
What should I do if my result shows two copies of APOE e4?
Start by confirming it with a clinical test that includes the rs429358 marker, especially if the report estimated your type from the neighboring marker rather than reading it directly. Two copies carries more weight than one, so it is a result to go through with your doctor or a genetic counselor rather than on your own. It is also the result where the report's guidance on dietary fat is most relevant, because e4 carriers appear to respond more strongly to the fat they eat.
Can I use this alongside my medication?
Yes, and share it with your doctor. Some supplements the report can suggest may interact with common medicines, including blood thinners, cholesterol medicines, and some antidepressants. Check any supplement or diet change with your doctor first, and do not stop or change a prescribed medicine on your own.
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