Stress, worry and your brain's calming signals, including anxiety
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
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You'll make your report on a computer with your DNA file. We email you the link, so you can buy now and do it later.
Works with your 23andMe, Ancestry, MyHeritage or other raw DNA file
Runs in your browser. Your DNA file is never uploaded or stored
How it works
1Buy the report We email you a sign-in link.
2Attach your DNA file It's read on your computer.
3Read your report Your report is ready in a few minutes, as a PDF to keep.
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version.
File access and refunds
Requesting your file from 23andMe? It's usually ready in about a week, and sometimes takes up to 30 days. Get your DNA file
You can get a refund within 14 days of purchase if you haven't accessed or started generating your report
“Excellent, detailed reports with actionable info.”
How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 82 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
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Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
The science behind it, if you want it
The full biology of anxiety, the HPA axis, neurotransmitter pathways, and methylation, for when you or your practitioner want to go deeper.
Chapters in this report
Anxiety
HPA Axis And Anxiety Disorders
Anxiety, HPA-Axis, Methylation And Epigenetics
Nutrients That Affect Methylation
As titled in the example report.
2
Your Recommendations Summary
A ranked list of nutrients, foods, and lifestyle factors scored by the combined strength of your genetic signal. The place to start.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CFood sits in the same list. A low oxalate diet ranks alongside the supplements, so you can start with what you eat.
DSupplements name the exact form, here nicotinamide riboside chloride for NAD+, because the form affects how well your body can use it.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
3
Where your genes disagree
Where genes pull in opposite directions on the same intervention, both scores are shown so you and your practitioner can make an informed call.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the report
In this example, Quercetin scores 507 for Focus and 11 for Avoid.
It ranks higher on the Focus side, and the Avoid score still counts.
Items that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
4
One page for each gene
Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
5
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for IL-6. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 82 genes across these areas.
The HPA axis and cortisol regulation
GABA and inhibitory signaling
Dopamine and catecholamine balance
Serotonin production and transport
Oxytocin and social stress
Adenosine signaling and arousal
BDNF and neuroplasticity
Methylation and nutrient foundations
Dietary and metabolic genetics
See every area and gene
The HPA axis and cortisol regulation. The core stress response system: how your brain triggers cortisol release, how well your body regulates it, and whether the feedback loop that turns it off is working (CRHR1, CRHR2, FKBP5, NR3C1).
GABA and inhibitory signaling. Whether your brain produces enough GABA to quiet neural excitability and hold a calm baseline. Deficits here are linked to panic disorder and generalized anxiety (GAD1).
Dopamine and catecholamine balance. How quickly your brain clears dopamine, adrenaline, and norepinephrine, your baseline dopamine tone, and how stress affects neurotransmitter levels (COMT, DAT1/SLC6A3, DRD2, MAOB).
Serotonin production and transport. How efficiently your body makes serotonin and how well it regulates serotonin signaling across different receptor subtypes (TPH1, TPH2, SLC6A4, HTR1A, HTR2A, HTR3B, HTR3E).
Oxytocin and social stress. How your brain handles the oxytocin response involved in social bonding, emotional regulation, and dampening stress reactivity. Variants here are particularly relevant to social anxiety (OXTR).
Adenosine signaling and arousal. How your brain modulates arousal and excitability through adenosine, and how stimulants interact with your specific receptor sensitivity (ADORA2A).
BDNF and neuroplasticity. How well your brain maintains and repairs neural connections under stress. BDNF is one of the key links between the HPA axis and long-term mood resilience (BDNF, NCAM1).
Methylation and nutrient foundations. The biochemical foundation the entire stress response system depends on: B vitamin activation, folate processing, histamine clearance, and methylation capacity (MTHFR, MTHFS, MTHFD1, COMT, AHCY, CBS, and more).
Dietary and metabolic genetics. How your body processes fat, carbohydrate, and key micronutrients, and how dietary patterns interact with your anxiety-related gene variants (APOE4, FADS1, FADS2, PPARG, PPARA, ADIPOQ, LEPR).
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is for anyone who has tried several anxiety interventions with inconsistent results and wants to understand why. It is equally useful for practitioners who want a genetic roadmap before designing a protocol, and for anyone who has noticed that their anxiety has a biological quality to it: predictable triggers, a specific character, or a response to stress that feels hard-wired rather than circumstantial.
It is the most comprehensive anxiety genetics report Noorns offers, covering every major pathway from cortisol regulation to neurotransmitter clearance to the methylation cycle that supports them all.
The science, briefly
Why the same intervention works for one person and not another
If magnesium, ashwagandha, or cutting caffeine helped someone else but not you, your genes may be part of the reason.
COMT, the Warrior-Worrier gene
COMT breaks down stress-related neurotransmitters. Slow and fast variants affect their clearance differently, which can change how stress feels.
In your reportThe report uses your genotype to distinguish support for slower clearance from support for lower baseline dopamine.
Read the full explanation
COMT breaks down dopamine, adrenaline, and norepinephrine. If you carry the slow variant (AA genotype), these neurotransmitters clear slowly. You may feel calm in routine life but become overwhelmed under stress, when COMT activity drops further and catecholamines spike. If you carry the fast variant (GG genotype), clearance is efficient but dopamine is lower at baseline. Knowing your genotype tells you whether the problem is buildup under stress or too little dopamine support at rest, and each calls for a different approach.
FKBP5, your cortisol off-switch
FKBP5 helps control the brake on the cortisol response. Variants that weaken that brake can let the stress response run longer.
In your reportThe report identifies lifestyle inputs tied to this pathway, alongside the other stress-related genes it reads.
Read the full explanation
FKBP5 regulates the sensitivity of the glucocorticoid receptor, the molecular brake that tells the HPA axis to stop producing cortisol after a stressor passes. Variants that increase FKBP5 expression weaken that brake, so the stress response runs longer than it should. This is one of the clearest genetic mechanisms behind chronic anxiety and stress-related disorders, and it responds to specific lifestyle inputs that this report identifies.
ADORA2A and why caffeine makes some people anxious
Caffeine blocks adenosine receptors, including the one made by ADORA2A. A particular variant can make that effect more anxiety-provoking.
In your reportThe report checks this pathway to help explain why coffee may affect you differently from someone else.
Read the full explanation
The ADORA2A gene encodes the adenosine A2A receptor, which has a calming, inhibitory effect on the brain. Caffeine works by blocking adenosine receptors, and in people with a specific ADORA2A variant that block causes a disproportionate spike in neural excitability and anxiety. If you have always felt that coffee affects you differently from other people, this may be part of why.
Those are three of the mechanisms. The report covers 82 genes across the whole stress response system.
More on the science behind this report
Two people can both describe themselves as anxious and be experiencing completely different biology. One may produce less GABA, the neurotransmitter that quiets neural activity, because of a GAD1 variant. Another may have a cortisol regulation problem because a FKBP5 variant leaves their HPA axis, the body's central stress-response system, stuck in overdrive after stress. A third may carry a COMT variant that lets dopamine and adrenaline build up faster than they are cleared. All three feel anxious. None of them will respond well to the same intervention.
This is the problem with generic anxiety advice. Magnesium helps some people significantly and barely touches others. Ashwagandha calms some and does nothing for others. Caffeine is fine for most people but can trigger panic in those with a specific ADORA2A variant. Genes are a large part of that difference.
This report reads the genes behind your stress response system from top to bottom: the HPA axis, neurotransmitter production and clearance, cortisol regulation, and the methylation cycle that underpins all of it. It tells you which pathways are under strain in your specific biology, and what to do about each one.
Private by design
Your DNA file stays on your computer
Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
No. You pay once for this report, and there's nothing to renew or cancel.
Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
You need raw data from 23andMe, Ancestry, MyHeritage, or another DNA service. We do not sell kits, so order a test from one of them first, then download your raw data file from their site.
Can I do it on my phone?
For now, generating your report works best on a computer. Once it's ready, you can read the PDF on any device.
What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
Is this report only useful if I have an anxiety diagnosis?
No. Many people use it to understand stress sensitivity, sleep quality, emotional reactivity, or why certain substances affect them the way they do. An anxiety diagnosis is not required.
How is this different from other mental health DNA reports?
Most reports in this space look at one or two neurotransmitter genes. This report maps the whole system: the HPA axis that governs cortisol, the GABA and serotonin pathways, dopamine and catecholamine clearance, oxytocin signaling, BDNF, adenosine regulation, and the methylation cycle that underpins all of it.
Can I use this alongside my current treatment?
Yes, and that is how it is intended to be used. The report is designed to inform conversations with your practitioner, not to replace them. Always discuss any supplement or dietary changes with your healthcare provider, especially if you are taking medication.
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