When stress and low energy feed each other: your stress response (HPA axis) and methylation
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
$39 One time, no subscription
You'll make your report on a computer with your DNA file. We email you the link, so you can buy now and do it later.
Works with your 23andMe, Ancestry, MyHeritage or other raw DNA file
Runs in your browser. Your DNA file is never uploaded or stored
How it works
1Buy the report We email you a sign-in link.
2Attach your DNA file It's read on your computer.
3Read your report Your report is ready in a few minutes, as a PDF to keep.
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version.
File access and refunds
Requesting your file from 23andMe? It's usually ready in about a week, and sometimes takes up to 30 days. Get your DNA file
You can get a refund within 14 days of purchase if you haven't accessed or started generating your report
“I also got the one-on-one consultation with the genetic counselor and was thrilled with the experience. Very clear and efficient. Highly recommended!”
How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 65 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
“Reports are quick to receive and easy to understand. One of my favorite companies to deal with and get information from.”
Val P.
“I also used other reports in past but none even compare to the length and detail of Noorns…!”
Danielle
“I really learned alot about myself and the science behind it. Best decision moneywise and I use the advice every day now.”
Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
The science behind it, if you want it
The full biology of the HPA axis and cortisol, the methylation cycle, choline and riboflavin, and how methylation shapes the stress response, for when you or your practitioner want to go deeper.
Chapters in this report
HPA Axis
HPA-Axis, Methylation And Epigenetics
As titled in the example report.
2
Your Recommendations Summary
A ranked list of foods, nutrients, and lifestyle factors to focus on or avoid, highest priority first, scored by the combined strength of your genetic signal. The place to start.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CFood sits in the same list. Foods rich in vitamin C rank alongside the supplements, so you can start with what you eat.
DSupplements name the exact form, here nicotinamide riboside chloride for NAD+, because the form affects how well your body can use it.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
3
Where your genes disagree
Where genes pull in opposite directions on the same intervention, both scores are shown so you and your practitioner can make an informed call.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the report
In this example, Methylfolate scores 260 for Focus and 109 for Avoid.
It ranks higher on the Focus side, and the Avoid score still counts.
Items that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
4
One page for each gene
Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
5
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for CRHR2. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 65 genes across these areas.
The HPA axis and cortisol regulation
The methylation cycle
Neurotransmitter and histamine clearance
Sulfur, detoxification and protein handling
Vitamin and mineral needs
Dietary and metabolic genetics
Blood pressure, uric acid and oxalate
See every area and gene
The HPA axis and cortisol regulation. Variants studied in cortisol signaling and feedback (CRHR1, CRHR2, POMC, NR3C1, FKBP5).
The methylation cycle. Genes studied in making and recycling methyl groups, which the report uses to set your needs for folate, B12, riboflavin, B6, and choline (SLC19A1, DHFR, MTHFS, MTHFD1, MTHFR, MTR, MTRR, PEMT, BHMT, AHCY, CBS, COMT).
Neurotransmitter and histamine clearance. Genes studied in breaking down serotonin, dopamine, adrenaline, and histamine (MAOA, MAOB, HNMT, AOC1/DAO, ALDH2, FMO3).
Sulfur, detoxification and protein handling. How you process sulfur compounds, build glutathione, clear certain chemicals and medicines, and handle the nitrogen from protein (SUOX, GSS, NAT1, NAT2, CYP1A2, CPS1).
Vitamin and mineral needs. How efficiently you activate and use vitamins D, A, B6, and B12, and how you absorb and store iron (CYP2R1, GC, VDR, BCO1, FUT2, NBPF3, HFE, TF, TMPRSS6).
Dietary and metabolic genetics. How your body handles fat, carbohydrate, fructose, and lactose (FADS1, FADS2, ADIPOQ, PGC-1α, PPARG, PPARA, PPARGC1B, ACAT1, LIPC, APOE, CETP, APOA2, FTO, LEPR, IRS1, LCT, CLTCL1, ALDOB).
Blood pressure, uric acid and oxalate. Genes linked to blood pressure, cholesterol particles, uric acid, and the oxalate that can form kidney stones (ACE, AGT, LPA, SLC2A9, ABCG2, SPP1, AGXT, GRHPR, HOGA1).
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is for people who want their stress-response genes read together with their methylation and dietary genes, and turned into one plan they can act on or bring to a practitioner.
The same DNA file powers every Noorns report.
How it compares with our other reports
Methylation and Diet Report. The methylation cycle, neurotransmitter and histamine clearance, vitamin needs, and dietary genetics.
Stress and Energy Report. Nearly all of the Methylation and Diet genes, plus five stress-response genes (CRHR1, CRHR2, POMC, NR3C1, FKBP5) and a Science Deep Dive on the HPA axis. If you own the Methylation and Diet Report, those five genes and the HPA deep dive are what this adds.
Anxiety and Calm Report. Every gene in this report, plus the GABA, serotonin, dopamine, oxytocin, adenosine, and BDNF genes. If you own the Anxiety and Calm Report, this report adds no new genes.
The science, briefly
Why the same stress protocol works differently for different people
If you want to know how your genes shape your stress response and your nutrient needs, this report reads both.
NR3C1, FKBP5 and the cortisol off-switch
NR3C1 and FKBP5 help wind down the stress response. Some variants can make this off-switch less sensitive, but life history matters too.
In your reportThe report lists food and stress-reduction supports for these genes. Your DNA file shows your variants, not your history or current cortisol levels.
Read the full explanation
NR3C1 makes the glucocorticoid receptor, which cortisol binds to tell the brain to wind the stress response down. FKBP5 makes that receptor less sensitive, so higher FKBP5 levels can weaken the off-switch. In one study, a common FKBP5 variant raised the risk of stress-related conditions only in adults who faced childhood trauma, seemingly through lasting chemical tags on the gene without changing the DNA. For these genes, the report suggests regular stress-reduction practices such as meditation, yoga, or massage, omega-3 fats, and keeping vitamin D out of the low range. Your file shows the variant but not your history, and the study did not test these general supports.
MTHFR, COMT and methyl balance
MTHFR uses vitamin B2 to help the folate cycle work. In a trial, B2 lowered homocysteine only in people with two copies of a common variant.
In your reportThe report also reads COMT to put B vitamin forms and methyl-donor tolerance in context.
Read the full explanation
MTHFR's enzyme makes the active folate your methylation cycle runs on and needs riboflavin (vitamin B2). Two copies of a common variant make it less active. In a randomized trial, riboflavin lowered homocysteine, a marker of how well the cycle works, by 22 percent in people with two copies, with no effect in people carrying one copy or none. The report also reads COMT, since methyl-donor tolerance depends partly on how fast COMT clears stress chemicals like adrenaline, and suggests sensitive people start B vitamins at very low doses.
FADS1 and omega-3
FADS1 helps convert plant omega-3 into EPA. A common nearby variant was associated with differences in blood fatty acid levels.
In your reportFor carriers, the report gives more weight to fatty fish rather than relying on plant omega-3 alone.
Read the full explanation
FADS1 helps turn the omega-3 in plant foods into EPA, a longer omega-3 fat. In a genome-wide study, a common variant near FADS1, which this report reads, was strongly associated with blood levels of EPA and other fatty acids. For carriers, the report leans toward fatty fish and a Mediterranean or pescatarian pattern instead of relying on plant sources alone, and away from seed oils high in linoleic acid.
Those are three of the mechanisms. The report covers 65 genes across seven pathways.
More on the science behind this report
Your stress response is meant to switch on when you need it and switch off once the pressure passes. The genes behind that switch vary from person to person, and so do the genes that shape your nutrient needs. Advice written for everyone does not account for either.
Two systems sit underneath this. The HPA axis is the chain of signals from your brain to your adrenal glands that controls cortisol, your main stress hormone. Methylation is the process that attaches small chemical tags to your DNA to turn genes up or down, and it also helps your body make neurotransmitters. The two are linked, because research suggests methylation on some stress genes can affect how well the stress response switches off.
This report reads the genes behind both systems, along with the dietary genetics that shape your nutrient needs, and turns them into one ranked, food-first plan.
Private by design
Your DNA file stays on your computer
Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
No. You pay once for this report, and there's nothing to renew or cancel.
Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
You need raw data from 23andMe, Ancestry, MyHeritage, or another DNA service. We do not sell kits, so order a test from one of them first, then download your raw data file from their site.
Can I do it on my phone?
For now, generating your report works best on a computer. Once it's ready, you can read the PDF on any device.
What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
Does this report test my cortisol?
No. It reads variants in genes studied in cortisol signaling and feedback. Cortisol itself is measured with lab tests ordered by a practitioner.
Can I use this if I take medication for mood, anxiety, or sleep?
Yes, as information for you and your practitioner. Some of the supplements the report may suggest act on mood chemistry, so do not start any without checking with your doctor, and do not change medication based on the report.
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