Energy, focus and the B vitamins your genes handle best, including MTHFR
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
$29 One time, no subscription
You'll make your report on a computer with your DNA file. We email you the link, so you can buy now and do it later.
Works with your 23andMe, Ancestry, MyHeritage or other raw DNA file
Runs in your browser. Your DNA file is never uploaded or stored
How it works
1Buy the report We email you a sign-in link.
2Attach your DNA file It's read on your computer.
3Read your report Your report is ready in a few minutes, as a PDF to keep.
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version.
File access and refunds
Requesting your file from 23andMe? It's usually ready in about a week, and sometimes takes up to 30 days. Get your DNA file
You can get a refund within 14 days of purchase if you haven't accessed or started generating your report
“I also got the one-on-one consultation with the genetic counselor and was thrilled with the experience. Very clear and efficient. Highly recommended!”
How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 61 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
“I really learned alot about myself and the science behind it. Best decision moneywise and I use the advice every day now.”
Stefan O.
“With my health, Noorns helped me to stop throwing darts in the dark and got me to the bullseye of the matter.”
Lindsey S.
“Reports are quick to receive and easy to understand. One of my favorite companies to deal with and get information from.”
Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
Start here
One page tells you how to use the rest: skim the summary, pick one to three changes, look up the why only when you want it, and change one thing at a time.
How the report says to start
Called “START HERE: How To Use This Report” in the reportThe report's own four steps. From an example report made with a sample DNA file.
2
The science behind it, if you want it
The full biology of all six pathways, for when you or your practitioner want to understand the why. It is optional, since everything you need to act on is in the Recommendations Summary.
Chapters in this report
Methylation, DNA And Epigenetics
MTHFR And Folate
MTHFR And Choline
MTHFR And Riboflavin
Methylation Cycle Genetics
Histamine And Methylation
As titled in the example report.
3
Your Recommendations Summary
A ranked list of foods, nutrients, and lifestyle factors to focus on or avoid, highest priority first, each scored by how strongly your genetics support it.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CFood sits in the same list. Foods rich in vitamin C rank alongside the supplements, so you can start with what you eat.
DSupplements name the exact form, here nicotinamide riboside chloride for NAD+, because the form affects how well your body can use it.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
4
Where your genes disagree
When different genes pull in opposite directions, the report shows you both scores instead of hiding the tension. You see the strength of each signal and can make an informed decision with your practitioner.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the report
In this example, Methylfolate scores 278 for Focus and 109 for Avoid.
It ranks higher on the Focus side, and the Avoid score still counts.
Items that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
5
One page for each gene
A plain-English page for each gene, with a clear table of the variants you carry, what they mean, and the specific changes tied to them.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
6
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for VDR. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 61 genes across these areas.
The methylation cycle
Neurotransmitter synthesis and BH4 recycling
Histamine metabolism and clearance
Transsulfuration and detoxification
Vitamin and nutrient metabolism
Dietary and metabolic genetics
See every area and gene
This report reads 61 genes across these areas, including a dedicated dietary genetics section covering the nutrients and food patterns most relevant to your methylation capacity:
The methylation cycle. How efficiently your body produces and recycles methyl groups (MTHFR, MTHFS, MTHFD1, DHFR, SLC19A1, AHCY, MTR, MTRR, PEMT, BHMT, CBS).
Neurotransmitter synthesis and BH4 recycling. How your body produces and clears dopamine, serotonin, and norepinephrine, and whether BH4 recycling keeps nitric oxide production on track (COMT, MAOB, QDPR, GSS).
Histamine metabolism and clearance. How well your gut and cells break down histamine from food and from your own immune response (AOC1/DAO, HNMT, ALDH2, FMO3, SUOX).
Transsulfuration and detoxification. How your body converts homocysteine into cysteine, glutathione, and taurine, and how it handles certain compounds from diet and environment (CBS, SUOX, NAT1, NAT2, CPS1).
Vitamin and nutrient metabolism. How efficiently you absorb and activate key vitamins including D, A, B12, and iron (VDR, GC, CYP2R1, BCO1, TF, TMPRSS6, FUT2, LCT, CYP1A2).
Dietary and metabolic genetics. How your body handles fat, glucose, inflammation, and circadian eating, through the genes that interact most directly with what and when you eat (APOE4, FTO, LEPR, PPARG, PPARA, PPARGC1B, FADS1, FADS2, ADIPOQ, IRS1, CETP, LIPC, APOA2, ACE, AGT, ABCG2, SLC2A9).
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is most useful if you have struggled with fatigue, brain fog, mood instability, histamine symptoms, or unexplained B vitamin issues and have never had a genetic explanation. It is also the right starting point if you work with a practitioner who wants a rigorous genetic foundation for nutrient protocols, or if you already have DNA data and want to understand what it means for your daily choices.
It pairs naturally with the Weight and Metabolism Report, and the same DNA file powers every Noorns report.
The science, briefly
Why the same protocol works differently for different people
If you have tried B vitamins, folate, or methylfolate and felt no real difference, the answer may be in which form your genes handle well. This report shows you.
Some of the strongest findings in nutrigenomics are not about the nutrient on its own. They are about the interaction between a gene and what you eat or supplement.
MTHFR and B vitamin form
MTHFR helps turn folate into the form your body uses. Common variants can affect that process, so the same B vitamin form may not suit everyone.
In your reportYour report shows your variants and ranks folate forms among your priorities. Planning a pregnancy? Folic acid is the form proven in trials to prevent neural tube defects.
Read the full explanation
Folic acid, the form in most supplements and fortified foods, goes through several steps before it becomes methylfolate, the form your body uses to recycle homocysteine. MTHFR handles the last step. People with two copies of the common C677T variant have about 15 percent lower blood folate on the same intake. Methylfolate skips those steps and raises folate at least as well, so some people prefer it. Your report shows your variants and ranks folate forms among your priorities. Planning a pregnancy? Folic acid is the form proven in trials to prevent neural tube defects.
COMT and neurotransmitter clearance
COMT helps clear dopamine and norepinephrine. It relies on SAMe from the methylation cycle, linking these two pathways.
In your reportThe report uses your COMT genotype to inform where to start with folate, B12, methyl donors and caffeine.
Read the full explanation
COMT uses SAMe, produced by the methionine cycle, to break down dopamine and norepinephrine. When methylation is impaired and SAMe production drops, neurotransmitter clearance slows. Knowing your COMT genotype helps you choose where to start: which forms of folate and B12 to begin with, how quickly to add methyl donors, and how much caffeine suits you.
DAO, HNMT and histamine tolerance
DAO clears histamine in the gut; HNMT clears it inside cells. Variants can slow either pathway, and HNMT also depends on methylation.
In your reportThe report looks at both clearance routes to identify which food and lifestyle suggestions apply to your variants.
Read the full explanation
Histamine intolerance is often put down to food sensitivity when the real issue is a clearance bottleneck. Variants in DAO reduce histamine breakdown in the gut, and variants in HNMT slow clearance inside your cells. Because HNMT uses SAMe as its methyl donor, impaired methylation makes histamine intolerance worse. Knowing which clearance pathways are under strain tells you which foods, supplements, and lifestyle changes apply to you.
That is the case for personalization in three findings. The average recommendation has to cover everyone. Yours does not.
More on the science behind this report
Methylation is a system of six interconnected biochemical pathways running continuously in every cell of your body: the folate cycle, the methionine cycle, the transsulfuration pathway, the neurotransmitter and BH4 recycling system, the urea cycle, and the nitric oxide pathway. Together they govern DNA repair, gene expression, neurotransmitter clearance, detoxification, and immune regulation.
These pathways depend on each other, so a bottleneck in one creates pressure across all the others. Reduced activity in the MTHFR enzyme slows folate conversion, which limits homocysteine recycling in the methionine cycle, which increases the load on the transsulfuration pathway through CBS. If CBS also carries variants, cysteine production drops and glutathione falls, reducing your antioxidant capacity. One variant can ripple across the entire system.
This is why generic advice on B vitamins and folate is often wrong for the people who need it most. The right nutrient depends on which parts of the pathway are under pressure in your specific biology, not on population averages.
Private by design
Your DNA file stays on your computer
Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
No. You pay once for this report, and there's nothing to renew or cancel.
Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
You need raw data from 23andMe, Ancestry, MyHeritage, or another DNA service. We do not sell kits, so order a test from one of them first, then download your raw data file from their site.
Can I do it on my phone?
For now, generating your report works best on a computer. Once it's ready, you can read the PDF on any device.
What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
How is this different from other methylation reports?
Most methylation reports cover MTHFR and a handful of related genes. This report covers 61 genes across all six pathways that interact with the methylation cycle, including histamine clearance, neurotransmitter metabolism, transsulfuration, and the dietary genetics that decide which foods support or strain your pathways.
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