Headaches and their triggers, and the genes and nutrients behind migraines
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
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“Excellent, detailed reports with actionable info.”
How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 58 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
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Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
Your Recommendations Summary
A ranked list of foods, nutrients, and lifestyle factors scored by the combined signal across all your variants. The practical starting point.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CFood sits in the same list. Vitamin A rich meats rank alongside the supplements, so you can start with what you eat.
DSupplements name the exact form, here pyridoxal 5'-phosphate for vitamin B6, because the form affects how well your body can use it.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
2
Where your genes disagree
Where genes point in different directions on the same intervention, both scores are shown instead of hiding the tension.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the report
In this example, Paleo diet scores 245 for Focus and 7 for Avoid.
It ranks higher on the Focus side, and the Avoid score still counts.
Items that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
3
The science behind it, if you want it
The full biology of migraine, from histamine and glutamate to serotonin, nitric oxide, and methylation, for when you or your practitioner want to understand the mechanisms behind your recommendations.
Chapters in this report
FKBP5-Chronic Pain
As titled in the example report.
4
One page for each gene
Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
5
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for BDNF. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 58 genes across these areas.
Histamine clearance
Serotonin and pain signaling
Migraine risk genes from genetic studies
Blood vessels and nitric oxide
Stress and chronic pain
Oxidative stress and brain resilience
Methylation and B vitamins
Dietary and metabolic genetics
See every area and gene
Histamine clearance. How efficiently your body breaks down histamine, which research links to headache in sensitive people (AOC1/DAO, HNMT).
Serotonin and pain signaling. How your serotonin and opioid receptors, and related brain chemistry, shape your sensitivity to pain and your migraine risk (HTR2A, HTR1B, HTR2C, OPRM1, DBH).
Migraine risk genes from genetic studies. Variants reported in genetic studies of migraine (MTDH, TRPM8, AJAP1, ITPK1, and a marker on chromosome 8).
Blood vessels and nitric oxide. How your blood vessels make and respond to nitric oxide, a molecule that widens them (NOS3, NOS2, MRVI1, PHACTR1).
Stress and chronic pain. How your stress-hormone system and related genes respond to pressure, and how that feeds into chronic pain and headache (FKBP5, SERPINA1, SERPINA6).
Oxidative stress and brain resilience. How well your brain handles oxidative stress, clears cellular waste, and keeps its nerve connections and fluid barriers stable (PRDM16, BDNF, LRP1, ASTN2).
Methylation and B vitamins. How you process folate, B12, riboflavin, and B6, and how quickly you clear dopamine and adrenaline (MTHFR, MTRR/MTR, MTHFS, COMT, NBPF3, FUT2).
Dietary and metabolic genetics. How your body handles fats, blood sugar, cholesterol, iron, and uric acid, so the plan fits the rest of your biology (FADS1, FADS2, CETP, APOE4, FTO, TCF7L2, HFE, SLC2A9, and more).
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is for people who live with migraine and want a gene-based nutrition and lifestyle list to discuss with their doctor. It is particularly relevant if you have tried trigger diets, supplements, or medication with mixed results, or if migraine runs in your family.
If histamine looks like part of your picture, the MCAS and Histamine Report goes further into mast cells and histamine. The Methylation and Diet Report covers the B vitamin pathways in more depth.
The science, briefly
How genes and migraine nutrition connect in this report
If you want to see which foods, nutrients, and habits your genes point to for migraine, this report gives you a ranked list to talk through with your doctor.
DAO and histamine
DAO breaks down histamine. The report reads markers linked to making less of this enzyme, but the evidence connecting these markers to migraine support is indirect.
In your reportFor relevant variants, the report weighs low-histamine choices and flags particular foods and drinks. It does not promise fewer attacks.
Read the full explanation
AOC1 makes diamine oxidase (DAO), which breaks down histamine. There is substantial evidence that histamine given into the body can set off and worsen headache. A small Spanish study linked differences in the DAO gene to migraine, most clearly in women. The report reads other DAO markers, ones linked to making less of the enzyme. If yours point that way, it favors a low-histamine diet and flags histamine-rich foods, black and green tea, and several yellow food colorings. The support is indirect. In a trial of a DAO supplement in people with migraine and low blood DAO activity, attacks became shorter, but the difference from placebo was not clear.
TRPM8 and menthol
TRPM8 is a cold sensor that also responds to menthol. A marker read by the report has been associated with migraine in genetic studies.
In your reportThe report may suggest topical menthol and gentle warmth. Evidence for menthol in migraine remains preliminary.
Read the full explanation
TRPM8 makes the body's main cold sensor, which also responds to menthol, the compound that makes mint feel cool. A TRPM8 marker this report reads was among the top signals in a genome-wide migraine study of over 23,000 people, and held up in later studies. For your variants, the report may suggest menthol on the skin during an attack and gentle warmth, not cold therapy. A review of herbal treatments found positive but preliminary results for menthol in migraine generally, from studies at high risk of bias.
PRDM16 and exercise
A PRDM16 marker has been linked to migraine, though its role is unclear. The report includes regular exercise among its suggestions.
In your reportExercise reduced attacks in one trial, but that trial did not select people by PRDM16 genotype or include a placebo group.
Read the full explanation
The same study linked a PRDM16 marker this report reads to migraine, though the gene's role is unclear. The report ties PRDM16 to oxidative stress and weight, and its suggestions include regular exercise. In a randomized trial of 91 adults with migraine, 40 minutes of exercise three times a week cut attacks by about one a month, similar to relaxation training or the preventive drug topiramate. The trial had no placebo group and did not select by PRDM16 genotype.
Those are three of the mechanisms. The report covers 58 genes, grouped below into eight pathways.
More on the science behind this report
Migraine runs in families. Research puts the inherited share of migraine risk at up to 57 percent, and a 2022 genome-wide study of more than 100,000 people with migraine found 123 regions of the genome associated with it. The genes this report reads touch several different systems, including histamine clearance, B vitamin processing, and how nerves sense cold and pain.
This report reads 58 genes. More than 20 of them sit in systems research links to migraine, from histamine clearance and serotonin signaling to blood vessel tone, stress hormones, and the methylation cycle. The rest cover how your body handles fats, blood sugar, and other nutrients. For each gene, the report looks at your variants and lists the foods, nutrients, and habits it suggests, then ranks them into one list.
Think of it as a discussion aid. Use it with your doctor, alongside a headache diary, to decide which nutrition and lifestyle changes are worth trying and to track whether they help.
Private by design
Your DNA file stays on your computer
Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
No. You pay once for this report, and there's nothing to renew or cancel.
Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
You need raw data from 23andMe, Ancestry, MyHeritage, or another DNA service. We do not sell kits, so order a test from one of them first, then download your raw data file from their site.
Can I do it on my phone?
For now, generating your report works best on a computer. Once it's ready, you can read the PDF on any device.
What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
Is this useful if I get headaches but have no migraine diagnosis?
It can be. Several of the genes in this report are linked to headache and pain more broadly, including the serotonin and blood vessel pathways. The report cannot tell you what kind of headache you have, so if your headaches are new, changing, or severe, see a doctor first.
Can I use this alongside my migraine medication?
Yes, as a discussion aid alongside your treatment. Check any new supplement with your doctor or pharmacist, and talk to the doctor who prescribed a medicine before you change it because of anything in the report.
How is this different from keeping a trigger diary?
A diary records what happened before an attack. This report suggests foods, nutrients, and habits to test based on your variants, such as a low-histamine diet if your DAO markers point that way. The diary then shows whether a change helped. The two work best together.
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