Reactions to food and your surroundings, including mast cell activation (MCAS)
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
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How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 67 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
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Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
The science behind it, if you want it
The biology of mast cell activation, how MCAS differs from mastocytosis, histamine metabolism, and why histamine symptoms can shift across the menstrual cycle, for when you or your practitioner want to understand the mechanisms.
Chapters in this report
Mast Cell Activation Disease
Mast Cells, Histamine And Methylation
As titled in the example report.
2
Your Recommendations Summary
A ranked, prioritized list of nutrients, foods, and lifestyle factors scored by the combined strength of your genetic signal. The practical starting point.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CFood sits in the same list. A low histamine diet ranks alongside the supplements, so you can start with what you eat.
DSupplements name the exact form, here pyridoxal 5'-phosphate for vitamin B6, because the form affects how well your body can use it.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
3
Where your genes disagree
Where genes pull in different directions on the same intervention, both scores are shown instead of hiding the tension.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the report
In this example, Folinic acid/Calcium Folinate scores 290 for Focus and 70 for Avoid.
It ranks higher on the Focus side, and the Avoid score still counts.
Items that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
4
One page for each gene
Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
5
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for IL-4R. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 67 genes across these areas.
Mast cell growth and activation
Inflammatory signaling
Histamine production and clearance
Methylation and B vitamins
Detoxification
Vitamins D and A, and iron
Gut, oxalate, and uric acid
Dietary and metabolic genetics
See every area and gene
Mast cell growth and activation. What switches your mast cells on, through IgE or around it, and the allergy-leaning Th2 messengers that keep reactions going (KIT, FCER1A, IL-33, IL-4, IL-4R, IL-5, IL-13).
Inflammatory signaling. How strongly your body makes the inflammatory messengers that prime mast cells (IL-6, TNF-alpha, TGFB1).
Histamine production and clearance. How much histamine you make, and how quickly your gut and cells break it down and clear what is left (HDC, AOC1/DAO, HNMT, MAOA, MAOB, ALDH2).
Methylation and B vitamins. The methylation cycle that HNMT relies on to break down histamine inside your cells, and the forms of folate and B vitamins the report suggests for your variants (MTHFR, MTHFS, MTHFD1, DHFR, SLC19A1, MTR, MTRR, PEMT, BHMT, CBS, COMT, NBPF3).
Detoxification. How you process compounds such as tyramine, glutamate, caffeine, and some medicines (FMO3, NAT1, NAT2, CYP1A2, CPS1).
Vitamins D and A, and iron. How you activate vitamins D and A, and how you transport and store iron (VDR, GC, CYP2R1, BCO1, HFE, TF, TMPRSS6).
Gut, oxalate, and uric acid. Lactose tolerance and B12 absorption in the gut, and how your body handles oxalate and uric acid (FUT2, LCT, AGXT, GRHPR, HOGA1, SPP1, SLC2A9, ABCG2).
Dietary and metabolic genetics. How your body processes fat, cholesterol, and carbohydrate, and the eating pattern the report suggests for your variants (APOE4, FADS1, FADS2, PPARG, PPARA, ADIPOQ, CETP, LIPC, FTO, LEPR, ACE, and more).
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is for anyone living with flushing, hives, itching, stomach reactions, or a growing list of food and medicine sensitivities who suspects their mast cells or histamine intolerance are involved, with or without a diagnosis. Practitioners can use it before designing a protocol.
This report and the Eczema and Skin Report share the same mast cell and histamine core. If eczema or reactive skin is part of your picture, choose the Eczema and Skin Report, which adds the skin barrier gene FLG and two more immune genes. If your reactions are mainly in your gut, head, or heart, choose this report. It is built around whole-body mast cell reactions, and it adds TNF-alpha, an inflammatory messenger gene the skin report does not read. For autoimmune-like patterns or chronic inflammation, see the Immune Balance Report, which adds 14 more immune genes.
The science, briefly
Why the same MCAS protocol helps one person and not another
If you react to more and more things and your allergy tests keep coming back clear, part of the answer may be in the genes that switch your mast cells on and clear the histamine they release.
IL-33 and reactions without an allergy
IL-33 is an alarm signal that can activate mast cells without IgE in lab studies. This may help explain reactions despite clear allergy tests.
In your reportFor relevant variants, the report lists vitamin C, quercetin and vitamin D, and flags green tea extract. The lab findings are not a diagnosis.
Read the full explanation
IL-33 is an alarm signal released when the gut or airway lining is inflamed. In a study of lab-grown human mast cells, it prompted them to release inflammatory messengers without IgE. IgE is the antibody most allergy tests measure, so this may help explain reactions when those tests come back clear. Variants near IL-33 were linked to asthma in a genetic study of more than 26,000 people. For carriers, the report suggests vitamin C, quercetin, and vitamin D, and flags green tea extract (EGCG) to avoid.
ALDH2 and the alcohol flush
ALDH2 clears by-products of alcohol breakdown. Slow variants can cause flushing and may contribute to reactions involving histamine.
In your reportThe report points carriers away from alcohol and toward low-histamine food choices, with nutrient suggestions tied to the gene.
Read the full explanation
ALDH2 clears aldehydes, the by-products of breaking down alcohol and, further along, histamine. Slow variants cause the facial flush some people get from one drink, seen in about a third of people of East Asian ancestry. In a small study of Japanese adults with asthma, alcohol narrowed airways in 3 of 16 with the usual gene and 10 of 14 with one slow copy, and the reaction tracked rises in blood acetaldehyde and histamine. The report points carriers away from alcohol and toward a low-histamine diet, with vitamin C and magnesium.
IL-6 and a primed mast cell
In lab work, prolonged exposure to IL-6 made mast cells multiply and react more strongly. The report links some variants to higher background inflammation.
In your reportFor carriers, it gives more weight to fruits, vegetables, herbs and spices, and flags processed foods and smoking.
Read the full explanation
In laboratory work at the US National Institutes of Health, long exposure to IL-6, an inflammatory messenger, made human mast cells grown in the lab multiply and react more strongly when triggered. The report links some IL-6 variants to higher background inflammation and, for carriers, suggests fruits, vegetables, herbs, and spices over processed foods, processed omega-6 oils, and smoking.
Those are three of the mechanisms. The report covers 67 genes across eight areas.
More on the science behind this report
For some people, mast cell activation syndrome (MCAS) feels like being allergic to almost everything. Flushing, hives, stomach pain, brain fog, a racing heart, and reactions to foods or medicines can come in episodes, across the skin, gut, nervous system, and heart. Mast cells are immune cells that store histamine and other chemical messengers, and in MCAS they release them too easily and too often.
MCAS is hard to manage partly because the problem can sit at several points along one chain: the signals that switch mast cells on, the background inflammation that keeps them primed, and how quickly your body clears the histamine they release. Genes influence each of those steps, and a protocol aimed at the wrong step can leave you doing everything right with little to show for it.
This report reads the genes across the mast cell and histamine pathways and turns them into a ranked, food-first protocol matched to your variants.
Private by design
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Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
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Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
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What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
How is this different from the Eczema and Skin Report?
The two reports share the same mast cell and histamine core: the signals that switch mast cells on, the inflammatory messengers that keep them primed, and the histamine clearance chain. The Eczema and Skin Report adds three genes, including one for the skin barrier, so choose it if eczema or reactive skin is part of your picture. This report is built around whole-body mast cell reactions, and it adds TNF-alpha, an inflammatory messenger gene the skin report does not read.
Is this useful if my allergy tests came back normal?
It can be. Mast cells can be switched on by signals that do not involve IgE. The report looks at genes along those routes as well as the IgE route, which can help make sense of reactions that an allergy panel does not explain.
Can I use this alongside my current treatment?
Yes, and that is how it is intended. Share it with your allergist, immunologist, or integrative practitioner, and check any supplement or diet change with them first. Some common medicines are known to block DAO, the main enzyme that clears histamine from food, and the report names the ones it covers so you can raise them with your prescriber. Do not stop a prescribed medicine on your own.
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