Your skin barrier and skin reactions, including eczema (atopic dermatitis)
Pages from an example report made with a sample DNA file.
Turn the DNA file you already have into a ranked list of the foods, nutrients and lifestyle changes to focus on and avoid, with the research behind it linked gene by gene.
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You'll make your report on a computer with your DNA file. We email you the link, so you can buy now and do it later.
Works with your 23andMe, Ancestry, MyHeritage or other raw DNA file
Runs in your browser. Your DNA file is never uploaded or stored
How it works
1Buy the report We email you a sign-in link.
2Attach your DNA file It's read on your computer.
3Read your report Your report is ready in a few minutes, as a PDF to keep.
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version.
File access and refunds
Requesting your file from 23andMe? It's usually ready in about a week, and sometimes takes up to 30 days. Get your DNA file
You can get a refund within 14 days of purchase if you haven't accessed or started generating your report
“I also got the one-on-one consultation with the genetic counselor and was thrilled with the experience. Very clear and efficient. Highly recommended!”
How this report compares with other DNA tools and chatbots
If you've already run your file through another tool or asked a chatbot, here's what each one gives you, side by side.
What you getWhat to do nextWhen your genes disagreeCan you check it?
Noorns
This report
What you get
A ranked summary of the foods, nutrients and lifestyle changes to focus on and avoid, each with a priority score, weighed across the 69 genes this report reads
What to do next
Food first, with supplements named in the exact form
When your genes disagree
Both scores shown side by side, with what they mean
Can you check it?
The research behind each gene, listed with links at the back
Not from Noorns
A gene lookup tool
What you get
A table of your variants, gene by gene
What to do next
Up to you to work out
When your genes disagree
Up to you to weigh
Can you check it?
Varies by tool
Not from Noorns
An AI chatbot
What you get
A quick answer in plain words to the question you ask
What to do next
Suggestions, which can get a variant wrong
When your genes disagree
Depends on what you ask
Can you check it?
Hard to check
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Real pages from an example report made with a sample DNA file. Yours follows the same order, with your own results.
1
The science behind it, if you want it
The full biology of atopic dermatitis, mast cell activation, histamine metabolism, and the immune pathways involved, for when you or your practitioner want to understand the mechanisms behind your recommendations.
Chapters in this report
Mast Cells
Mast Cells, Histamine And Methylation
As titled in the example report.
2
Your Recommendations Summary
A ranked, prioritized list of nutrients, foods, and lifestyle factors scored by the combined strength of your genetic signal. The practical starting point, covering everything from dietary histamine load to specific mast cell stabilizers to barrier repair.
AYour Focus list. Foods, nutrients and habits to lean into, with the highest priority at the top. An Avoid list follows.
BThe number in brackets is the item's score. Scores are a priority scale. The more of your genes that point to an item, the higher it ranks. They show you where to start, not a guarantee of results.
CFood sits in the same list. A low histamine diet ranks alongside the supplements, so you can start with what you eat.
DSupplements name the exact form, here pyridoxal 5'-phosphate for vitamin B6, because the form affects how well your body can use it.
Talk to your doctor before you start a supplement.
Your foods, rankedABCDCalled “Recommendations Summary” in the reportThe top of a Focus list, with four lettered notes. Your scores will differ. From an example report made with a sample DNA file.
3
Where your genes disagree
Where genes pull in different directions on the same intervention, both scores are shown instead of hiding the tension.
1Two scores for one item. The Focus score weighs the variants that point toward it, and the Avoid score weighs the ones that point away.
2The higher score shows which way it leans. More of your genes point that way, and the other score still counts.
3What the scores can't tell you. They show genetic tendencies, not how your body is responding today. When the two are close, the report suggests talking that item through with your practitioner before acting on it.
Both scores, shownCalled “Conflicts” in the report
In this example, Folinic acid/Calcium Folinate scores 290 for Focus and 70 for Avoid.
It ranks higher on the Focus side, and the Avoid score still counts.
Items that appear in both lists, with both scores side by side. From an example report made with a sample DNA file.
4
One page for each gene
Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.
One page per geneYou: the two letters read from the DNA file at that spot. Risk: the letter studies link to the effect described for that gene.From an example report made with a sample DNA file.
5
The research, linked
At the back, the studies behind each gene are listed with their links, gene by gene, so you or your practitioner can read the sources.
Sources for every geneCalled “Appendix & References” in the reportThe references for IL-4R. From an example report made with a sample DNA file.
The genes it reads
This report analyzes 69 genes across these areas.
Skin barrier integrity
Mast cell reactivity and IgE signaling
Histamine production and clearance
Th2 and inflammatory cytokine balance
Methylation and immune foundations
Vitamin D and immune modulation
Dietary and metabolic genetics
See every area and gene
Skin barrier integrity. The genetic foundation of your skin's physical defense against allergens and irritants, and the nutritional inputs for barrier repair and maintenance (FLG).
Mast cell reactivity and IgE signaling. How easily your mast cells trigger and how strongly they respond to IgE binding, the core mechanism in both atopic dermatitis and mast cell activation syndrome (FCER1A, KIT, TSLP, TGFB1).
Histamine production and clearance. How efficiently your body produces and breaks down histamine in the gut and inside cells, and which clearance pathway is most likely to be your bottleneck (HDC, AOC1/DAO, HNMT, ALDH2, FMO3).
Th2 and inflammatory cytokine balance. How your immune system regulates the Th2 response that drives atopic inflammation, and the dietary and botanical inputs with the strongest evidence for modulating it (TSLP, TGFB1, COMT).
Methylation and immune foundations. The biochemical backbone of histamine clearance, immune regulation, and skin cell turnover. Shortfalls here amplify reactivity across every other pathway (MTHFR, MTHFS, MTHFD1, COMT, AHCY, CBS, BHMT, PEMT, MTR, MTRR, SLC19A1).
Vitamin D and immune modulation. How efficiently your body activates and uses vitamin D, which plays a direct role in regulating the immune responses involved in atopic dermatitis and mast cell function (VDR, GC, CYP2R1, BCO1).
Dietary and metabolic genetics. How your body processes fat, particularly the omega-3 to omega-6 ratio that has the most direct impact on inflammation in skin and immune tissue (FADS1, FADS2, PPARG, PPARA, PPARGC1B, APOE4, ADIPOQ, LEPR, CETP, LIPC).
Is it right for you
Who it's for, and what it doesn't do
Who it's for
This report is for anyone living with chronic skin reactivity, unexplained allergic symptoms, histamine sensitivity, or suspected mast cell overactivation who wants to understand the genetic layer driving it. It is equally valuable for practitioners working with complex, multi-system immune presentations who want a genetic roadmap before designing a protocol.
It is particularly relevant if elimination diets and antihistamines have given you partial or inconsistent relief, if your symptoms span several systems such as skin, gut, and nervous system, or if you have always felt that your immune system is unusually reactive without a clear explanation.
The science, briefly
Why the same protocol helps one person and not another
If elimination diets and antihistamines have only ever half worked, the missing piece may be which of your immune pathways is under the most strain.
FLG and the skin barrier
FLG makes filaggrin, a protein in the skin barrier. Variants can leave that barrier more vulnerable to moisture loss and incoming irritants.
In your reportYour FLG result helps the report decide how much priority to give barrier support.
Read the full explanation
FLG makes filaggrin, the protein that holds the skin's outer layer together and keeps allergens, bacteria, and irritants out. FLG variants are the single strongest genetic risk factor for atopic dermatitis, leaving microscopic gaps that let triggers in and moisture out. For carriers, barrier repair comes first, and borage oil, omega-6 fatty acids, and specific probiotic strains have the strongest evidence. Your FLG status tells you whether barrier support should be your foundation or a secondary concern.
FCER1A and IgE-driven mast cell reactions
FCER1A makes the IgE receptor on mast cells. Variants associated with higher IgE can make this reaction pathway more relevant.
In your reportThe report uses your genotype to weigh mast cell and histamine support alongside skin-barrier support.
Read the full explanation
FCER1A encodes the high-affinity IgE receptor on mast cells. When IgE binds to it, the cell releases histamine, prostaglandins, and cytokines. Variants are associated with higher IgE and a hair-trigger mast cell response. For carriers, quercetin and vitamin C are the most evidence-backed mast cell stabilizers, phosphatidylcholine and activated charcoal have evidence for calming gut mast cells when IgE is confirmed high, and a low-histamine diet also applies. Your genotype tells you how hard to lean on this layer.
HNMT, DAO and histamine clearance
DAO clears histamine in the gut; HNMT clears it inside cells. Variants can slow either route, and HNMT also depends on the methylation cycle.
In your reportThe report maps both pathways to show which clearance bottleneck deserves more attention.
Read the full explanation
Histamine intolerance is usually less about how much histamine you eat than about the balance between how much comes in and how fast you clear it. DAO (AOC1) clears histamine in the gut and HNMT clears it inside cells. Variants in either let histamine from food, immune activation, and mast cells build up faster than it is broken down. HNMT runs on SAMe from the methylation cycle, so impaired methylation makes histamine intolerance worse. The report maps both pathways and tells you which is your main bottleneck.
Those are three of the mechanisms. The report covers 69 genes across seven pathways.
More on the science behind this report
Atopic dermatitis affects roughly one in five people at some point in their lives. For many, it is a lifelong cycle of flares, partial remission, and renewed sensitivity with no clear trigger. The same is true for people living with mast cell overactivation: a broad, shifting set of symptoms spanning skin, gut, nervous system, and cardiovascular function that can take years to identify and longer to manage.
These conditions are hard to pin down because they are the end result of several biological systems: skin barrier integrity, IgE receptor sensitivity, histamine production and clearance, cytokine signaling, and the methylation cycle that underpins immune function. Each of these varies from person to person based on genetics. When you know which system is most under strain in your biology, you have a far more precise target than any generic protocol can give you.
This report maps the genetics of your skin and immune reactivity from the surface barrier down to the cellular level, and gives you a ranked, evidence-based protocol for each layer.
Private by design
Your DNA file stays on your computer
Your DNA file is never uploaded or stored.
The report is built inside your own web browser, on your own computer, so your file is read where it already is. Privacy is enforced by architecture, not by a policy you have to trust.
No. You pay once for this report, and there's nothing to renew or cancel.
Will it work with my DNA file?
Raw data files from 23andMe, Ancestry, MyHeritage and SelfDecode work today. Tested somewhere else? Email info@noorns.com and we'll tell you whether your file works.
What if I don't have a DNA file yet?
You need raw data from 23andMe, Ancestry, MyHeritage, or another DNA service. We do not sell kits, so order a test from one of them first, then download your raw data file from their site.
Can I do it on my phone?
For now, generating your report works best on a computer. Once it's ready, you can read the PDF on any device.
What if my file doesn't work, or a run doesn't finish?
Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If your file can't produce a report, we'll reset your run or refund you. If something else goes wrong, email info@noorns.com and we'll do our best to make it right.
Can I get a refund?
Yes. You can get a refund within 14 days of purchase if you haven't accessed or started generating your report. If your file can't produce a report, we'll reset your run or refund you. Email info@noorns.com.
Will my report update when new research comes out?
Yes, when we update the report. Each purchase includes up to three report runs, for a retry, a lost PDF or an updated version. If we add new research while you still have a run left, run it again and you get the new version.
Do I need to be an expert to use it?
No. Most people read the Recommendations Summary, change a few things starting with food, and give it time. The gene pages and Science Deep Dive are there for when you want to go deeper, or when you are working through the results with a practitioner.
Is this report useful if I have not been diagnosed with atopic dermatitis or MCAS?
Yes. Many people with variants in these pathways have milder symptoms: some histamine sensitivity, reactive skin, seasonal allergies, or fatigue after certain foods. The report is useful for anyone who suspects their immune system is running hotter than it should, even without a formal diagnosis.
How is this different from a standard allergy test?
Allergy tests identify the specific allergens your immune system is reacting to now. This report looks at why your immune system is reactive in the first place: the genes that affect your mast cell threshold, histamine clearance, skin barrier, and inflammatory balance. The two work together.
Can I use this alongside my current treatment?
Yes, and that is how it is intended. The report is designed to inform conversations with your dermatologist, allergist, or integrative practitioner. Always discuss supplement or dietary changes with your healthcare provider, particularly if you are taking antihistamines, corticosteroids, or biologics.
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