{"product_id":"migraine","title":"Migraine Report","description":"\u003cdiv style=\"background:#f6f2fc;border-radius:12px;padding:18px 22px;margin:0 0 22px\"\u003e\n\u003cul style=\"margin:0;padding-left:18px\"\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eFor you if\u003c\/strong\u003e you live with migraine and want a gene-based nutrition and lifestyle list to discuss with your doctor.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eYou get\u003c\/strong\u003e a PDF report built around one short, ranked list of what to eat, add, and avoid.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eYou need\u003c\/strong\u003e the raw DNA file you already have from 23andMe, Ancestry, MyHeritage, or another DNA service. No new test.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003ePrivate by design.\u003c\/strong\u003e The report runs in your browser. Your DNA is never uploaded or stored.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eReady in 3 to 10 minutes,\u003c\/strong\u003e with a 14-day refund if you have not started generating it.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv style=\"margin-top:12px\"\u003e\u003ca href=\"\/#shopify-section-template--30864476143961__section_tUjXVr\" style=\"color:#ce446e;text-decoration:underline\"\u003e\u003cstrong\u003eGet a free example report before you buy\u003c\/strong\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003eIf you want to see which foods, nutrients, and habits your genes point to for migraine, this report gives you a ranked list to talk through with your doctor.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eMigraine runs in families. Research puts the inherited share of migraine risk at \u003cstrong\u003eup to 57 percent\u003c\/strong\u003e, and a 2022 genome-wide study of more than 100,000 people with migraine found \u003cstrong\u003e123 regions of the genome\u003c\/strong\u003e associated with it. The genes this report reads touch several different systems, including histamine clearance, B vitamin processing, and how nerves sense cold and pain.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eThis report reads 58 genes. More than 20 of them sit in systems research links to migraine, from histamine clearance and serotonin signaling to blood vessel tone, stress hormones, and the methylation cycle. The rest cover how your body handles fats, blood sugar, and other nutrients. For each gene, the report looks at your variants and lists the foods, nutrients, and habits it suggests, then ranks them into one list.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eThink of it as \u003cstrong\u003ea discussion aid\u003c\/strong\u003e. Use it with your doctor, alongside a headache diary, \u003cstrong\u003eto decide which nutrition and lifestyle changes are worth trying\u003c\/strong\u003e and to track whether they help.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch3\u003eHow genes and migraine nutrition connect in this report\u003c\/h3\u003e\n\u003cdiv\u003eThree examples from this report:\u003c\/div\u003e\n\u003cul\u003e\n\u003cli style=\"margin-bottom:1em\"\u003e\u003cspan\u003e\u003cstrong\u003eDAO and histamine.\u003c\/strong\u003e AOC1 makes diamine oxidase (DAO), which breaks down histamine. There is substantial evidence that histamine given into the body can set off and worsen headache. A small Spanish study linked differences in the DAO gene to migraine, most clearly in women. The report reads other DAO markers, ones linked to making less of the enzyme. If yours point that way, it favors a low-histamine diet and flags histamine-rich foods, black and green tea, and several yellow food colorings. The support is indirect. In a trial of a DAO supplement in people with migraine and low blood DAO activity, attacks became shorter, but the difference from placebo was not clear.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"margin-bottom:1em\"\u003e\u003cspan\u003e\u003cstrong\u003eTRPM8 and menthol.\u003c\/strong\u003e TRPM8 makes the body's main cold sensor, which also responds to menthol, the compound that makes mint feel cool. A TRPM8 marker this report reads was among the top signals in a genome-wide migraine study of over 23,000 people, and held up in later studies. For your variants, the report may suggest menthol on the skin during an attack and gentle warmth, not cold therapy. A review of herbal treatments found positive but preliminary results for menthol in migraine generally, from studies at high risk of bias.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"margin-bottom:1em\"\u003e\u003cspan\u003e\u003cstrong\u003ePRDM16 and exercise.\u003c\/strong\u003e The same study linked a PRDM16 marker this report reads to migraine, though the gene's role is unclear. The report ties PRDM16 to oxidative stress and weight, and its suggestions include regular exercise. In a randomized trial of 91 adults with migraine, 40 minutes of exercise three times a week cut attacks by about one a month, similar to relaxation training or the preventive drug topiramate. The trial had no placebo group and did not select by PRDM16 genotype.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003eThose are three of the mechanisms. The report covers 58 genes, grouped below into eight pathways.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch3\u003eWhat the report analyzes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eHistamine clearance.\u003c\/strong\u003e How efficiently your body breaks down histamine, which research links to headache in sensitive people (AOC1\/DAO, HNMT).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eSerotonin and pain signaling.\u003c\/strong\u003e How your serotonin and opioid receptors, and related brain chemistry, shape your sensitivity to pain and your migraine risk (HTR2A, HTR1B, HTR2C, OPRM1, DBH).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eMigraine risk genes from genetic studies.\u003c\/strong\u003e Variants reported in genetic studies of migraine (MTDH, TRPM8, AJAP1, ITPK1, and a marker on chromosome 8).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eBlood vessels and nitric oxide.\u003c\/strong\u003e How your blood vessels make and respond to nitric oxide, a molecule that widens them (NOS3, NOS2, MRVI1, PHACTR1).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eStress and chronic pain.\u003c\/strong\u003e How your stress-hormone system and related genes respond to pressure, and how that feeds into chronic pain and headache (FKBP5, SERPINA1, SERPINA6).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eOxidative stress and brain resilience.\u003c\/strong\u003e How well your brain handles oxidative stress, clears cellular waste, and keeps its nerve connections and fluid barriers stable (PRDM16, BDNF, LRP1, ASTN2).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eMethylation and B vitamins.\u003c\/strong\u003e How you process folate, B12, riboflavin, and B6, and how quickly you clear dopamine and adrenaline (MTHFR, MTRR\/MTR, MTHFS, COMT, NBPF3, FUT2).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eDietary and metabolic genetics.\u003c\/strong\u003e How your body handles fats, blood sugar, cholesterol, iron, and uric acid, so the plan fits the rest of your biology (FADS1, FADS2, CETP, APOE4, FTO, TCF7L2, HFE, SLC2A9, and more).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhat you get\u003c\/h3\u003e\n\u003cdiv\u003eEvery Noorns report follows the same structure, built to cut through overwhelm and point you to action:\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eA Recommendations Summary.\u003c\/strong\u003e A ranked list of foods, nutrients, and lifestyle factors scored by the combined signal across all your variants. The practical starting point.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eA Conflicts section.\u003c\/strong\u003e Where genes point in different directions on the same intervention, both scores are shown instead of hiding the tension.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eGene-by-gene pages.\u003c\/strong\u003e Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eA Science Deep Dive.\u003c\/strong\u003e The full biology of migraine, from histamine and glutamate to serotonin, nitric oxide, and methylation, for when you or your practitioner want to understand the mechanisms behind your recommendations.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWho it is for\u003c\/h3\u003e\n\u003cdiv\u003eThis report is for people who live with migraine and want a gene-based nutrition and lifestyle list to discuss with their doctor. It is particularly relevant if you have tried trigger diets, supplements, or medication with mixed results, or if migraine runs in your family.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eIf histamine looks like part of your picture, the MCAS and Histamine Report goes further into mast cells and histamine. The Methylation and Diet Report covers the B vitamin pathways in more depth.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch3\u003eYour DNA file never leaves your computer\u003c\/h3\u003e\n\u003cdiv\u003eWhen you generate this report, the analysis runs entirely inside your own web browser, on your own device. We do not upload your DNA. We do not store it. We cannot read it. Privacy is enforced by architecture, not by a policy you have to trust.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch3\u003eHow it works\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eBuy the report.\u003c\/strong\u003e You get a sign-in link by email. There is no password to remember.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eAdd your DNA file.\u003c\/strong\u003e Select the raw data file you already have from 23andMe, Ancestry, MyHeritage, or another DNA service. It is read on your computer and never sent to us.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eGenerate and save.\u003c\/strong\u003e The analysis takes three to ten minutes in your browser, then hands you a PDF to keep. Keep the tab open while it runs.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003eA note on medical care\u003c\/h3\u003e\n\u003cdiv\u003eThis report is education about your genes and your nutrition. It does not diagnose migraine or replace your headache treatment. Talk to your doctor before you start a supplement or change a medication.\u003c\/div\u003e\n","brand":"Noorns","offers":[{"title":"Default Title","offer_id":56312857526617,"sku":"15851611062617","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0972\/8183\/5353\/files\/noorns-gallery-migraine-protocol-1.jpg?v=1791544790","url":"https:\/\/noorns.com\/products\/migraine","provider":"Noorns NuGen","version":"1.0","type":"link"}